By Judith Wenshuk, peptide research writer
Quick Answer: Melanotan-1 is a more selective analogue of alpha-melanocyte-stimulating hormone than Melanotan-2, studied primarily for pigmentation research with less pronounced appetite-related activity. It’s the compound behind the FDA-designated drug afamelanotide, which gives it a somewhat more established research and regulatory history than Melanotan-2.
Melanotan-1 is available in Canada through research peptide suppliers, studied primarily in pigmentation research contexts.
How It Works
Like Melanotan-2, Melanotan-1 activates melanocortin receptors involved in the body’s natural pigmentation response. The key difference is selectivity — Melanotan-1 is more targeted toward the pigmentation pathway specifically, with less of the broader appetite-related receptor activity associated with Melanotan-2.
What It’s Studied For
- Pigmentation research — its primary and most selective application
- Photoprotection-adjacent research — related to its underlying compound’s approved medical use for light-sensitivity conditions
Melanotan-1 vs. Melanotan-2
If you’re deciding between the two, the core tradeoff is selectivity versus broader activity — we’ve written a full comparison covering the practical differences.
Frequently Asked Questions
Is Melanotan-1 the same as Melanotan-2? No — they’re related but distinct compounds, with Melanotan-1 being more selective for pigmentation specifically.
Is Melanotan-1 available as a research compound in Canada? Yes — Melanotan-1 is available through research peptide suppliers in Canada.
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